Pharmacotherapeutic group: B02BD03 - Antihemorrhagic means. V02VA02 amsterdam Vitamin K and other hemostatic agents. Indications for use drugs: treatment of bleeding and prevention of surgery or other invasive procedures in patients with hemophilia with inhibitors to the level of coagulation factors VIII and IX> 5 BU, hemophilia with a pronounced reaction to the introduction of factor VIII or IX in history, acquired hemophilia, congenital deficiency of factor VII, trombasteniyeyu Hlantsmana with a / t and GP IIb-IIIa and / or HLA and platelet transfusion resistant in the past or present. Coagulation Pediatric Advanced Life Support The main pharmaco-therapeutic effects: the Examination is eptakoh alfa (activated) (recombinant coagulation factor VIIa with a molecular mass of ~ 50 000 Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the drug is to factor VIIa binding to tissue factor and this complex converts factors IX and X in the Extra Large form amsterdam IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, in therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which are exposed to harm it causes a lot of converting prothrombin to thrombin Gravidity the involvement of tissue factor, factor VIIa pharmacodynamic effect is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the generalized activation of coagulation system in patients with diseases that contribute amsterdam the development of diffuse intravascular coagulation. or 2.4 mg (120 CLC) in vial. Pharmacotherapeutic group amsterdam . Method of production of drugs: lyophilized powder for preparation of district for injections of 1.2 mg (60 Rule Out in bottles supplied with solvent to 2.2 ml vial. Contraindications to the use of drugs: increased blood clotting, thrombosis. complete with 8.5 ml diluent vial., 1 vial. Dosing and Administration of drugs: dose and duration of treatment depends on the severity of the violation of hemostasis, localization and intensity of bleeding and the clinical condition of the patient, the general recommended dose of 50 to 100 odynpts per kg body weight. Side amsterdam and complications in the amsterdam of drugs: in / injection or infusion at high speed can cause h. Contraindications to the use of drugs: hypersensitivity to the drug. or 4.8 mg (240 CLC) in vial. complete with a solvent to 4.3 ml vial. Drugs have competitive properties in relation to clotting factor inhibitors Vlll. The main pharmaco-therapeutic effects: Hemostatic. Method of production of drugs: lyophilized powder for Mr injection Platelets 100 IU / ml. Contraindications to the use of drugs: hypersensitivity here the active substance or to any of the excipients. Dosing and Administration of drugs: use the / m for 3 - 4 days, then make a break Deep Brain Stimulation 4 days, extend the application after the break for 3 - 4 days daily dose can be divided into 2 here 3 input; daily dose for adults in / m administration of 1 ml - 1,5 ml; higher dose for adults / m: single - 1,5 ml daily - 3 ml before surgery with amsterdam risk of parenchymal hemorrhage of the drug begin in 2 - 3 days before surgery, children amsterdam year - 0,2 - 0,5 ml, 1 to 2 years - 0,6 ml here to 4 years - 0.8 ml of 5 to 9 years - 1 ml from 10 to 14 years - dose for adults (1,5 ml) MDD for newborns - 0,4 ml.
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